NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106–126

PrP106–126, a peptide corresponding to residues 107–127 of the human prion protein, induces neuronal cell death by apoptosis and causes proliferation and hypertrophy of glia, reproducing the main neuropathological features of prion-related transmissible spongiform encephalopathies, such as bovine sp...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Kuwata, Kazuo, Matumoto, Tomoharu, Cheng, Hong, Nagayama, Kuniaki, James, Thomas L., Roder, Heinrich
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 2003
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299804/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14657385/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2433563100
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