Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure

Jun N-terminal kinase (JNK) is activated in cochlear hair cells following acoustic trauma or exposure to aminoglycoside antibiotics. Blockade of JNK activation using mixed lineage kinase (MLK) inhibitors prevents hearing loss and hair cell death following these stresses. Since current pharmacologic...

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Main Authors: Polesskaya, Oksana, Cunningham, Lisa L., Francis, Shimon P., Luebke, Anne E., Zhu, Xiaoxia, Collins, David, Vasilyeva, Olga N., Sahler, Julie, Desmet, Emily A., Gelbard, Harris A., Maggirwar, Sanjay B., Walton, Joseph P., Frisina, Robert D., Dewhurst, Stephen
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997883/
https://ncbi.nlm.nih.gov/pubmed/20971179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2010.10.008
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