Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure

Jun N-terminal kinase (JNK) is activated in cochlear hair cells following acoustic trauma or exposure to aminoglycoside antibiotics. Blockade of JNK activation using mixed lineage kinase (MLK) inhibitors prevents hearing loss and hair cell death following these stresses. Since current pharmacologic...

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Hauptverfasser: Polesskaya, Oksana, Cunningham, Lisa L., Francis, Shimon P., Luebke, Anne E., Zhu, Xiaoxia, Collins, David, Vasilyeva, Olga N., Sahler, Julie, Desmet, Emily A., Gelbard, Harris A., Maggirwar, Sanjay B., Walton, Joseph P., Frisina, Robert D., Dewhurst, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997883/
https://ncbi.nlm.nih.gov/pubmed/20971179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2010.10.008
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