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Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces

In this study we report on direct involvement of fluid shear stresses on the osteoblastic differentiation of marrow stromal cells. Rat bone marrow stromal cells were seeded in 3D porous titanium fiber mesh scaffolds and cultured for 16 days in a flow perfusion bioreactor with perfusing culture media...

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Detalhes bibliográficos
Main Authors: Sikavitsas, Vassilios I., Bancroft, Gregory N., Holtorf, Heidi L., Jansen, John A., Mikos, Antonios G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC299759/
https://ncbi.nlm.nih.gov/pubmed/14657343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2434367100
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