Induction of Immune Tolerance to a Therapeutic Protein by Intrathymic Gene Delivery

The efficacy of recombinant enzyme therapy for genetic diseases is limited in some patients by the generation of a humoral immune response to the therapeutic protein. Inducing immune tolerance to the protein prior to treatment has the potential to increase therapeutic efficacy. Using an AAV8 vector...

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Autors principals: Chu, Qiuming, Moreland, Rodney J, Gao, Lan, Taylor, Kristin M, Meyers, Elizabeth, Cheng, Seng H, Scheule, Ronald K
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997582/
https://ncbi.nlm.nih.gov/pubmed/20664526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.164
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