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Induction of Immune Tolerance to a Therapeutic Protein by Intrathymic Gene Delivery
The efficacy of recombinant enzyme therapy for genetic diseases is limited in some patients by the generation of a humoral immune response to the therapeutic protein. Inducing immune tolerance to the protein prior to treatment has the potential to increase therapeutic efficacy. Using an AAV8 vector...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997582/ https://ncbi.nlm.nih.gov/pubmed/20664526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.164 |
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