Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

Many of the virulence factors produced by the opportunistic human pathogen Pseudomonas aeruginosa are quorum-sensing (QS) regulated. Among these are rhamnolipids, which have been shown to cause lysis of several cellular components of the human immune system, e.g. monocyte-derived macrophages and pol...

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Main Authors: VAN GENNIP, MARIA, CHRISTENSEN, LOUISE DAHL, ALHEDE, MORTEN, PHIPPS, RICHARD, JENSEN, PETER ØSTRUP, CHRISTOPHERSEN, LARS, PAMP, SÜNJE JOHANNA, MOSER, CLAUS, MIKKELSEN, PER JENSEN, KOH, ANDREW Y., TOLKER-NIELSEN, TIM, PIER, GERALD B., HØIBY, NIELS, GIVSKOV, MICHAEL, BJARNSHOLT, THOMAS
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997331/
https://ncbi.nlm.nih.gov/pubmed/19594494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0463.2009.02466.x
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