Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2

BACKGROUND & AIMS: The tumor suppressor PTEN inhibits AKT2 signaling; both are aberrantly expressed in liver tumors. We investigated how PTEN and AKT2 regulate liver carcinogenesis. Loss of PTEN leads to spontaneous development of liver tumors from progenitor cells. We investiged how the loss of...

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Bibliografische gegevens
Hoofdauteurs: Galicia, Vivian A., He, Lina, Dang, Hien, Kanel, Gary, Vendryes, Christopher, French, Barbara A, Zeng, Ni, Bayan, Jennifer-Ann, Ding, Wei, Wang, Kasper S., French, Samuel, Birnbaum, Morris J., Rountree, C. Bart, Stiles, Bangyan L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997180/
https://ncbi.nlm.nih.gov/pubmed/20837017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.09.002
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