Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

T cell antigen receptor (TCR) and coreceptor ligation is thought to initiate signal transduction by inducing activation of the kinase Lck. Here we showed that catalytically active Lck was present in unstimulated naive T cells and thymocytes and was readily detectable in these cells in lymphoid organ...

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Hauptverfasser: Nika, Konstantina, Soldani, Cristiana, Salek, Mogjiborahman, Paster, Wolfgang, Gray, Adrian, Etzensperger, Ruth, Fugger, Lars, Polzella, Paolo, Cerundolo, Vincenzo, Dushek, Omer, Höfer, Thomas, Viola, Antonella, Acuto, Oreste
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996607/
https://ncbi.nlm.nih.gov/pubmed/20541955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.05.011
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