Anti-neutrophil cytoplasmic antibodies target sequential functional proteinase 3 epitopes in the sera of patients with Wegener's granulomatosis

Many patients with Wegener's granulomatosis (WG) have anti-neutrophil cytoplasmic antibodies (c-ANCA). Aside from being a diagnostic marker, these autoantibodies may play roles in disease pathogenesis. Proteinase 3 (PR3) is the primary target of c-ANCA in WG patient sera. Of 60 c-ANCA-positive...

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Autori principali: Bruner, B F, Vista, E S, Wynn, D M, Harley, J B, James, J A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2010
Soggetti:
Translational Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996593/
https://ncbi.nlm.nih.gov/pubmed/21077276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2010.04251.x
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