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Reduced proteasomal activity contributes to the accumulation of carbonylated proteins in chronic experimental autoimmune encephalomyelitis
We have recently shown that several carbonylated proteins, including GFAP, β-actin and β-tubulin, accumulate within cerebellar astrocytes during the chronic phase of MOG(35–55) peptide-induced EAE in C57BL/6 mice. Since protein carbonyls cannot be repaired and there is less oxidative stress in chron...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996488/ https://ncbi.nlm.nih.gov/pubmed/20950414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.07062.x |
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