Human IRGM Regulates Autophagy and Its Cell-Autonomous Immunity Functions Through Mitochondria

IRGM, a human immunity related GTPase, confers autophagic defense against intracellular pathogens by an unknown mechanism. Here we report the unexpected mode of IRGM action. IRGM showed differential affinity for mitochondrial lipid cardiolipin, translocated to mitochondria, affected mitochondrial fi...

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Bibliografische gegevens
Hoofdauteurs: Singh, Sudha B., Ornatowski, Wojciech, Vergne, Isabelle, Naylor, John, Delgado, Monica, Roberts, Esteban, Ponpuak, Marisa, Master, Sharon, Pilli, Manohar, White, Eileen, Komatsu, Masaaki, Deretic, Vojo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996476/
https://ncbi.nlm.nih.gov/pubmed/21102437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2119
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