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A Quantitative Study of the Effects of Chaotropic Agents, Surfactants, and Solvents on the Digestion Efficiency of Human Plasma Proteins by Trypsin

Plasma biomarkers studies are based on the differential expression of proteins between different treatment groups or between diseased and control populations. Most mass spectrometry-based methods of protein quantitation, however, are based on the detection and quantitation of peptides, not intact pr...

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Detalhes bibliográficos
Main Authors: Proc, Jennifer L., Kuzyk, Michael A., Hardie, Darryl B., Yang, Juncong, Smith, Derek S., Jackson, Angela M., Parker, Carol E., Borchers, Christoph H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996461/
https://ncbi.nlm.nih.gov/pubmed/20722421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr100656u
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