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Imbalance of ionic conductances contributes to diverse symptoms of demyelination

Fast axonal conduction of action potentials in mammals relies on myelin insulation. Demyelination can cause slowed, blocked, desynchronized, or paradoxically excessive spiking that underlies the symptoms observed in demyelination diseases. The diversity and timing of such symptoms are poorly underst...

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Detalhes bibliográficos
Main Authors: Coggan, Jay S., Prescott, Steven A., Bartol, Thomas M., Sejnowski, Terrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996432/
https://ncbi.nlm.nih.gov/pubmed/20974975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013798107
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