An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain

Proper centromere function is critical to maintain genomic stability and to prevent aneuploidy, a hallmark of tumors and birth defects. A conserved feature of all eukaryotic centromeres is an essential histone H3 variant called CENP-A that requires a centromere targeting domain (CATD) for its locali...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ranjitkar, Prerana, Press, Maximilian O., Yi, Xianhua, Baker, Richard, MacCoss, Michael J., Biggins, Sue
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995698/
https://ncbi.nlm.nih.gov/pubmed/21070971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.09.025
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