Stem cell factor/c-Kit signaling in in vitro cultures supports early mouse embryonic development by accelerating proliferation via a mechanism involving Akt-downstream genes

PURPOSE: Stem cell factor (SCF)/c-Kit regulates the proliferation and survival of germ cells or stem cells; however, little is known about the role of SCF/c-Kit in pre-implantation embryo development. METHODS: Using exogenous SCF supplementation and c-Kit siRNA injection, we investigated the role an...

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Autors principals: Lim, Jung Jin, Eum, Jin Hee, Lee, Jeoung Eun, Kim, Eun Sun, Chung, Hyung Min, Yoon, Tae Ki, Kim, Kye-Seong, Lee, Dong Ryul
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2010
Matèries:
Embryo Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995437/
https://ncbi.nlm.nih.gov/pubmed/20589425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-010-9449-9
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