The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets

Polycomb group (PcG) proteins are key regulators of stem-cell and cancer biology. They mainly act as repressors of differentiation and tumor-suppressor genes. One key silencing step involves the trimethylation of histone H3 on Lys27 (H3K27) by EZH2, a core component of the Polycomb Repressive Comple...

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Main Authors: Van Dessel, Nele, Beke, Lijs, Görnemann, Janina, Minnebo, Nikki, Beullens, Monique, Tanuma, Nobuhiro, Shima, Hiroshi, Van Eynde, Aleyde, Bollen, Mathieu
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995064/
https://ncbi.nlm.nih.gov/pubmed/20671031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq643
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