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NMR structure of the let-7 miRNA interacting with the site LCS1 of lin-41 mRNA from Caenorhabditis elegans

We have determined the 3D structure of a 34-nt RNA construct, herein named LCS1co, which mimics the interaction of let-7 microRNA (miRNA) to one of its complementary binding sites, LCS1, in the 3′-untranslated region of lin-41 mRNA by solution-state NMR spectroscopy. let-7 miRNAs control the timing...

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Detalhes bibliográficos
Main Authors: Cevec, Mirko, Thibaudeau, Christophe, Plavec, Janez
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995062/
https://ncbi.nlm.nih.gov/pubmed/20660479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq640
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