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Glut1 Deficiency: Inheritance Pattern Determined by Haploinsufficiency

Two families manifesting Glut1 deficiency syndrome (Glut1 DS) as an autosomal recessive trait are described. In one family, a severely affected boy inherited a mutated allele from his asymptomatic heterozygous mother. A de novo mutation developed in the paternal allele producing compound heterozygos...

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Autors principals: Rotstein, Michael, Engelstad, Kristin, Yang, Hong, Wang, Dong, Levy, Brynn, Chung, Wendy K., De Vivo, Darryl C.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994988/
https://ncbi.nlm.nih.gov/pubmed/20687207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22088
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