Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells.

Cultures of bovine adrenomedullary chromaffin cells accumulated 1-methyl-4-phenylpyridinium (MPP+) in a time- and concentration-dependent manner by a process that was prevented by desmethylimipramine. The subcellular localization of the incorporated [methyl-3H]MPP+ was examined by differential centr...

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書誌詳細
出版年:	Proc Natl Acad Sci U S A
主要な著者:	Reinhard, J F, Diliberto, E J, Viveros, O H, Daniels, A J
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 1987
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2891137/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.22.8160
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Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells.

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