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IL-2 as a therapeutic target for the restoration of Foxp3(+ )regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease
Peripheral immune tolerance requires a finely controlled balance between tolerance to self-antigens and protective immunity against enteric and invading pathogens. Self-reactive T cells sometimes escape thymic clonal deletion, and can subsequently provoke autoimmune diseases such as type 1 diabetes...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2010
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2994816/ https://ncbi.nlm.nih.gov/pubmed/21059266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-8-113 |
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