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Effects of Metformin in Experimental Stroke

BACKGROUND AND PURPOSE: AMP-activated protein kinase (AMPK) is an important sensor of energy balance. Stroke-induced AMPK activation is deleterious as both pharmacological inhibition and genetic deletion of AMPK are neuroprotective. Metformin is a known AMPK activator, but reduces stroke incidence i...

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主要な著者: Li, Jun, Benashski, Sharon E., Venna, Venugopal, McCullough, Louise D.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994809/
https://ncbi.nlm.nih.gov/pubmed/20847317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.110.589697
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