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Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells

Epigenetic silencing of tumor suppressor genes commonly occurs in human cancers via increasing DNA methylation and repressive histone modifications at gene promoters. However, little is known about how pathogenic environmental factors contribute to cancer development by affecting epigenetic regulato...

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Bibliografiske detaljer
Main Authors: Chen, Haobin, Kluz, Thomas, Zhang, Ronghe, Costa, Max
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994281/
https://ncbi.nlm.nih.gov/pubmed/20881000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq197
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