Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

Ezh2 functions as a histone H3 Lys 27 (H3K27) methyltransferase when comprising the Polycomb-Repressive Complex 2 (PRC2). Trimethylation of H3K27 (H3K27me3) correlates with transcriptionally repressed chromatin. The means by which PRC2 targets specific chromatin regions is currently unclear, but non...

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Bibliographic Details
Main Authors: Kaneko, Syuzo, Li, Gang, Son, Jinsook, Xu, Chong-Feng, Margueron, Raphael, Neubert, Thomas A., Reinberg, Danny
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2010
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994035/
https://ncbi.nlm.nih.gov/pubmed/21123648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1983810
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