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Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation

Hepatocellular carcinoma (HCC) is one of the most common solid cancers, representing the third cause of cancer-related death among cirrhotic patients. Treatment of advanced HCC has become a very active area of research. Perifosine, a new synthetic alkylphospholipid Akt inhibitor, has shown anti-tumo...

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Detalhes bibliográficos
Main Authors: Fei, Hong-rong, Chen, Geng, Wang, Jian-mei, Wang, Feng-ze
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993858/
https://ncbi.nlm.nih.gov/pubmed/20842425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-010-9299-4
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