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Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation

Hepatocellular carcinoma (HCC) is one of the most common solid cancers, representing the third cause of cancer-related death among cirrhotic patients. Treatment of advanced HCC has become a very active area of research. Perifosine, a new synthetic alkylphospholipid Akt inhibitor, has shown anti-tumo...

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Autors principals: Fei, Hong-rong, Chen, Geng, Wang, Jian-mei, Wang, Feng-ze
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993858/
https://ncbi.nlm.nih.gov/pubmed/20842425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-010-9299-4
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