Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin

Podoplanin is a small transmembrane protein required for development and function of the lymphatic vascular system. To investigate the effects of interfering with its function, we produced an Fc fusion protein of its ectodomain. We found that podoplanin-Fc inhibited several functions of cultured lym...

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Bibliografiske detaljer
Main Authors: Cueni, Leah N., Chen, Lu, Zhang, Hui, Marino, Daniela, Huggenberger, Reto, Alitalo, Annamari, Bianchi, Roberta, Detmar, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993634/
https://ncbi.nlm.nih.gov/pubmed/20716773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-278564
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