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Reduced Cardiac Contractile Force Due to Sympathovagal Dysfunction Mediates the Additive Hypotensive Effects of Limited-Access Regimens of Ethanol and Clonidine in Spontaneously Hypertensive Rats
Our previous attempts to investigate the long-term hemodynamic interaction between ethanol and clonidine in telemetered spontaneously hypertensive rats (SHRs) were hampered by the lack of a sustained hypotensive response to continuous clonidine exposure. This limitation was circumvented when we adop...
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Main Authors: | , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993557/ https://ncbi.nlm.nih.gov/pubmed/20864507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.173443 |
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