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Reduced Cardiac Contractile Force Due to Sympathovagal Dysfunction Mediates the Additive Hypotensive Effects of Limited-Access Regimens of Ethanol and Clonidine in Spontaneously Hypertensive Rats

Our previous attempts to investigate the long-term hemodynamic interaction between ethanol and clonidine in telemetered spontaneously hypertensive rats (SHRs) were hampered by the lack of a sustained hypotensive response to continuous clonidine exposure. This limitation was circumvented when we adop...

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Detalhes bibliográficos
Main Authors: El-Mas, Mahmoud M., Abdel-Rahman, Abdel A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993557/
https://ncbi.nlm.nih.gov/pubmed/20864507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.173443
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