Two Naturally Occurring Mutations in the Type 1 Melanin-Concentrating Hormone Receptor Abolish Agonist-Induced Signaling

The melanin-concentrating hormone (MCH) receptor type 1 (MCHR1) is a seven-transmembrane domain protein that modulates orexigenic activity of MCH, the corresponding endogenous peptide agonist. MCH antagonists are being explored as a potential treatment for obesity. In the current study, we examined...

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Detalhes bibliográficos
Main Authors: Goldstein, Carmit, Schroeder, Jonathan C., Fortin, Jean-Philippe, Goss, Jennifer M., Schaus, Scott E., Beinborn, Martin, Kopin, Alan S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993548/
https://ncbi.nlm.nih.gov/pubmed/20833795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.174029
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