Ecto-5′-Nucleotidase and Thiopurine Cellular Circulation: Association with Cytotoxicity

Thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used to treat acute lymphoblastic leukemia of childhood. To test the hypothesis that variation in the expression of genes within the “thiopurine pathway” might influence 6-MP and 6-TG sensitivity, we generated basal gene e...

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Main Authors: Li, Fang, Fridley, Brooke L., Matimba, Alice, Kalari, Krishna R., Pelleymounter, Linda, Moon, Irene, Ji, Yuan, Jenkins, Gregory D., Batzler, Anthony, Wang, Liewei, Weinshilboum, Richard M.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993460/
https://ncbi.nlm.nih.gov/pubmed/20855458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.035220
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