Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice

Myocardial infarction (MI) results in significant metabolic derangement, causing accumulation of metabolic by product, such as homocysteine (Hcy). Hcy is a nonprotein amino acid generated during nucleic acid methylation and demethylation of methionine. Folic acid (FA) decreases Hcy levels by remethy...

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Bibliographic Details
Main Authors: Qipshidze, Natia, Tyagi, Neetu, Sen, Utpal, Givvimani, Srikanth, Metreveli, Naira, Lominadze, David, Tyagi, Suresh C.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993194/
https://ncbi.nlm.nih.gov/pubmed/20802128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00577.2010
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