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Phosphorylated HSP20 modulates the association of thin-filament binding proteins: caldesmon with tropomyosin in colonic smooth muscle

Small heat shock proteins HSP27 and HSP20 have been implicated in regulation of contraction and relaxation in smooth muscle. Activation of PKC-α promotes contraction by phosphorylation of HSP27 whereas activation of PKA promotes relaxation by phosphorylation of HSP20 in colonic smooth muscle cells (...

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Bibliographische Detailangaben
Hauptverfasser: Somara, Sita, Gilmont, Robert R., Varadarajan, Saranyaraajan, Bitar, Khalil N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993172/
https://ncbi.nlm.nih.gov/pubmed/20829522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00479.2009
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