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A Reducible Polycationic Gene Vector Derived from Thiolated Low Molecular Weight Branched Polyethyleneimine Linked by 2-Iminothiolane
To improve transfection efficiency and reduce the cytotoxicity of polymeric gene vectors, reducible polycations (RPC) were synthesized from low molecular weight (MW) branched polyethyleneimine (bPEI) via thiolation and oxidation. RPC (RPC-bPEI(0.8kDa)) possessed a MW of 5 kDa~80 kDa, and 50%~70% of...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992579/ https://ncbi.nlm.nih.gov/pubmed/21071079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2010.08.079 |
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