Kdo(2)-Lipid A, a TLR4-specific Agonist, Induces de Novo Sphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy

Activation of RAW264.7 cells with a lipopolysaccharide specific for the TLR4 receptor, Kdo(2)-lipid A (KLA), causes a large increase in cellular sphingolipids, from 1.5 to 2.6 × 10(9) molecules per cell in 24 h, based on the sum of subspecies analyzed by “lipidomic” mass spectrometry. Thus, this stu...

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Detalhes bibliográficos
Main Authors: Sims, Kacee, Haynes, Christopher A., Kelly, Samuel, Allegood, Jeremy C., Wang, Elaine, Momin, Amin, Leipelt, Martina, Reichart, Donna, Glass, Christopher K., Sullards, M. Cameron, Merrill, Alfred H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992289/
https://ncbi.nlm.nih.gov/pubmed/20876532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.170621
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