Homocysteine, Another Risk Factor for Alzheimer Disease, Impairs Apolipoprotein E3 Function

Apolipoprotein E (apoE) ϵ4 and hyperhomocysteinemia are risk factors for Alzheimer disease (AD). The dimerization of apoE3 by disulfide bonds between cysteine residues enhances apoE3 function to generate HDL. Because homocysteine (Hcy) harbors a thiol group, we examined whether Hcy interferes with t...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Minagawa, Hirohisa, Watanabe, Atsushi, Akatsu, Hiroyasu, Adachi, Kayo, Ohtsuka, Chigumi, Terayama, Yasuo, Hosono, Takashi, Takahashi, Satoshi, Wakita, Hideaki, Jung, Cha-Gyun, Komano, Hiroto, Michikawa, Makoto
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2010
Aiheet:
Neurobiology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992271/
https://ncbi.nlm.nih.gov/pubmed/20889503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146258
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia