Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

The mammalian target of rapamycin (mTOR) functions in cells at least as two complexes, mTORC1 and mTORC2. Intensive studies have focused on the roles of mTOR in the regulation of cell proliferation, growth, and survival. Recently we found that rapamycin inhibits type I insulin-like growth factor (IG...

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Huvudupphovsmän: Liu, Lei, Luo, Yan, Chen, Long, Shen, Tao, Xu, Baoshan, Chen, Wenxing, Zhou, Hongyu, Han, Xiuzhen, Huang, Shile
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992269/
https://ncbi.nlm.nih.gov/pubmed/20937815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.141168
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