Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus

Type I interferons are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Type I interferon-inducible mRNAs are widely and concordantly overexpressed in the periphery and involved tissues of a subset of SLE patients, and provide utility as pharmacodynamic biomarkers to aid dose se...

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Hauptverfasser: Yao, Yihong, Higgs, Brandon W, Richman, Laura, White, Barbara, Jallal, Bahija
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991779/
https://ncbi.nlm.nih.gov/pubmed/20392292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2887
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