The Functional −765G→C Polymorphism of the COX-2 Gene May Reduce the Risk of Developing Crohn's Disease

BACKGROUND: Cyclooxygenase-2 (COX-2) is a key enzyme involved in the conversion of arachidonic acid into prostaglandins. COX-2 is mainly induced at sites of inflammation in response to proinflammatory cytokines such as interleukin-1α/β, interferon-γ and tumor necrosis factor-α produced by inflammato...

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Autori principali: de Vries, Hilbert S., te Morsche, Rene H. M., van Oijen, Martijn G. H., Nagtegaal, Iris D., Peters, Wilbert H. M., de Jong, Dirk J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991351/
https://ncbi.nlm.nih.gov/pubmed/21124790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015011
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