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Predicting direct protein interactions from affinity purification mass spectrometry data

BACKGROUND: Affinity purification followed by mass spectrometry identification (AP-MS) is an increasingly popular approach to observe protein-protein interactions (PPI) in vivo. One drawback of AP-MS, however, is that it is prone to detecting indirect interactions mixed with direct physical interact...

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Détails bibliographiques
Auteurs principaux: Kim, Ethan DH, Sabharwal, Ashish, Vetta, Adrian R, Blanchette, Mathieu
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991326/
https://ncbi.nlm.nih.gov/pubmed/21034440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-7188-5-34
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