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RNA recombination of coronaviruses: localization of neutralizing epitopes and neuropathogenic determinants on the carboxyl terminus of peplomers.

Murine coronaviruses undergo RNA recombination at a very high frequency. We have obtained a series of recombinant viruses using neutralizing monoclonal antibodies in conjunction with temperature-sensitive markers. All of the recombinants obtained have a crossover within gene C, which encodes the pep...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Makino, S, Fleming, J O, Keck, J G, Stohlman, S A, Lai, M M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299120/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2442761/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.18.6567
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