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VGLUT2-dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch

Itch can be suppressed by painful stimuli, but the underlying neural basis is unknown. We generated conditional null mice in which VGLUT2-dependent synaptic glutamate release from mainly Nav1.8-expressing nociceptors was abolished. These mice showed deficits in pain behaviors including mechanical pa...

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Detalhes bibliográficos
Main Authors: Liu, Yang, Samad, Omar Abdel, Zhang, Ling, Duan, Bo, Tong, Qingchun, Lopes, Claudia, Ji, Ru-Rong, Lowell, Bradford B, Ma, Qiufu
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991105/
https://ncbi.nlm.nih.gov/pubmed/21040853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.09.008
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