Addition of GM-CSF to trastuzumab stabilises disease in trastuzumab-resistant HER2+ metastatic breast cancer patients

BACKGROUND: One of the proposed mechanisms of trastuzumab-induced regression of human epidermal growth factor receptor 2-positive (HER2+) tumours includes facilitation of antibody-dependent cell-mediated cytotoxicity (ADCC). Granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates ADCC. We...

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Hlavní autoři: Cheng, Y C, Valero, V, Davis, M L, Green, M C, Gonzalez-Angulo, A M, Theriault, R L, Murray, J L, Hortobagyi, G N, Ueno, N T
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990606/
https://ncbi.nlm.nih.gov/pubmed/20877352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605918
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