The roles and mechanisms of PAR4 and P2Y(12)/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation

BACKGROUND AND PURPOSE: Activation of human platelets by thrombin is mediated predominately through two proteinase-activated receptors (PARs), PAR1 and PAR4. Phosphatidylinositol 3-kinase (PI3K) inhibition leads to reversible PAR1-mediated platelet aggregation, but has no effect on the stability of...

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Detalhes bibliográficos
Main Authors: Wu, Chin-Chung, Wu, Shih-Yun, Liao, Chieh-Yu, Teng, Che-Ming, Wu, Yang-Chang, Kuo, Sheng-Chu
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990161/
https://ncbi.nlm.nih.gov/pubmed/20880402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00921.x
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