Sensory neuron-specific GPCRs Mrgprs are itch receptors mediating chloroquine-induced pruritus

The cellular and molecular mechanisms mediating histamine-independent itch in primary sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side-effect of this widely used anti-malarial drug. Here we show that Mrgprs, a family of G protein-coupled receptors expressed excl...

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Detalhes bibliográficos
Main Authors: Liu, Qin, Tang, Zongxiang, Surdenikova, Lenka, Kim, Seungil, Patel, Kush N., Kim, Andrew, Ru, Fei, Guan, Yun, Weng, Hao-Jui, Geng, Yixun, Undem, Bradley J., Kollarik, Marian, Chen, Zhou-Feng, Anderson, David J., Dong, Xinzhong
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989405/
https://ncbi.nlm.nih.gov/pubmed/20004959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.11.034
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