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Molecular mechanical simulations on double intercalation of 9-amino acridine into d(CGCGCGC) X d(GCGCGCG): analysis of the physical basis for the neighbor-exclusion principle.

The neighbor-exclusion principle is one of the most general and interesting rules describing intercalative DNA binding by small molecules. It suggests that such binding can only occur at every other base-pair site, reflecting a very large negative cooperativity in the binding process. We have carrie...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Rao, S N, Kollman, P A
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1987
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Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298937/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3475700/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.16.5735
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