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Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation.

Positively charged lipophilic compounds, such as rhodamine 123, localize in mitochondria and are selectively accumulated and retained by carcinoma cells. It has been suggested that this phenotype may be exploited for selective killing of carcinoma cells by lipophilic cations. Here we report that dou...

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Detalhes bibliográficos
Main Authors: Weiss, M J, Wong, J R, Ha, C S, Bleday, R, Salem, R R, Steele, G D, Chen, L B
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC298874/
https://ncbi.nlm.nih.gov/pubmed/3474661
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