A Novel p53 Phosphorylation Site within the MDM2 Ubiquitination Signal: II. A MODEL IN WHICH PHOSPHORYLATION AT SER(269) INDUCES A MUTANT CONFORMATION TO p53

The p53 DNA-binding domain harbors a conformationally flexible multiprotein binding site that regulates p53 ubiquitination. A novel phosphorylation site exists within this region at Ser(269), whose phosphomimetic mutation inactivates p53. The phosphomimetic p53 (S269D) exhibits characteristics of mu...

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Detalhes bibliográficos
Main Authors: Fraser, Jennifer A., Madhumalar, Arumugam, Blackburn, Elizabeth, Bramham, Janice, Walkinshaw, Malcolm D., Verma, Chandra, Hupp, Ted R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988382/
https://ncbi.nlm.nih.gov/pubmed/20847049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.143107
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