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HIV-1 Vpr Loads Uracil DNA Glycosylase-2 onto DCAF1, a Substrate Recognition Subunit of a Cullin 4A-RING E3 Ubiquitin Ligase for Proteasome-dependent Degradation

The human immunodeficiency virus type 1 (HIV-1) accessory protein, Vpr, interacts with several host cellular proteins including uracil DNA glycosylase-2 (UNG2) and a cullin-RING E3 ubiquitin ligase assembly (CRL4(DCAF1)). The ligase is composed of cullin 4A (CUL4A), RING H2 finger protein (RBX1), DN...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ahn, Jinwoo, Vu, Thomas, Novince, Zach, Guerrero-Santoro, Jennifer, Rapic-Otrin, Vesna, Gronenborn, Angela M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988339/
https://ncbi.nlm.nih.gov/pubmed/20870715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.133181
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