Nucleophosmin C-terminal Leukemia-associated Domain Interacts with G-rich Quadruplex Forming DNA

Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling phosphoprotein, mainly localized at nucleoli, that plays a key role in ribogenesis, centrosome duplication, and response to stress stimuli. Mutations at the C-terminal domain of NPM1 are the most frequent genetic lesion in acute myeloid leukemia...

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Main Authors: Federici, Luca, Arcovito, Alessandro, Scaglione, Giovanni L., Scaloni, Flavio, Lo Sterzo, Carlo, Di Matteo, Adele, Falini, Brunangelo, Giardina, Bruno, Brunori, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988320/
https://ncbi.nlm.nih.gov/pubmed/20858903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166736
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