PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes

BACKGROUND: Protease-Activated Receptors (PARs), members of G-protein-coupled receptors, are activated by proteolytic activity of various proteases. Activation of PAR1 and PAR2 triggers innate immune responses in human oral keratinocytes (HOKs), but the signaling pathways downstream of PAR activatio...

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Bibliografiska uppgifter
Huvudupphovsmän: Rohani, Maryam G, DiJulio, Dennis H, An, Jonathan Y, Hacker, Beth M, Dale, Beverly A, Chung, Whasun O
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988058/
https://ncbi.nlm.nih.gov/pubmed/21029417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-11-53
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