PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes

BACKGROUND: Protease-Activated Receptors (PARs), members of G-protein-coupled receptors, are activated by proteolytic activity of various proteases. Activation of PAR1 and PAR2 triggers innate immune responses in human oral keratinocytes (HOKs), but the signaling pathways downstream of PAR activatio...

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Main Authors: Rohani, Maryam G, DiJulio, Dennis H, An, Jonathan Y, Hacker, Beth M, Dale, Beverly A, Chung, Whasun O
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988058/
https://ncbi.nlm.nih.gov/pubmed/21029417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-11-53
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