Lack of antibody affinity maturation due to poor Toll stimulation led to enhanced RSV disease

Respiratory syncytial virus (RSV) is a leading cause of hospitalization in infants. A formalin-inactivated RSV vaccine was used to immunize children in 1966 and elicited non-protective, pathogenic antibody. Two immunized infants died and 80% were hospitalized after subsequent RSV exposure. No vaccin...

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Detalhes bibliográficos
Main Authors: Delgado, Maria Florencia, Coviello, Silvina, Monsalvo, A. Clara, Melendi, Guillermina A., Hernandez, Johanna Zea, Batalle, Juan P., Diaz, Leandro, Trento, Alfonsina, Chang, Herng-Yu, Mitzner, Wayne, Ravetch, Jeffrey, Melero, José A., Irusta, Pablo M., Polack, Fernando P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987729/
https://ncbi.nlm.nih.gov/pubmed/19079256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1894
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