Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes.
We demonstrate that blockade of the lymphocyte voltage-gated K+ channel by charybdotoxin (CTX) inhibits lymphocyte mitogenesis. Charybdotoxin blocks conductance with a Ki of 0.3 nM and inhibits mitogen- and antigen-stimulated proliferation with a Ki of 0.5 nM. As opposed to the other blockers of the...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1989
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2481312/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.24.10171 |
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