Characterization of a t(5;8)(q31;q21) translocation in a patient with mental retardation and congenital heart disease: implications for involvement of RUNX1T1 in human brain and heart development

The chromosome break points of the t(8;21)(q21.3;q22.12) translocation associated with acute myeloid leukemia disrupt the RUNX1 gene (also known as AML1) and the RUNX1T1 gene (also known as CBFA2T3, MTG8 and ETO) and generate a RUNX1–RUNX1T1 fusion protein. Molecular characterization of the transloc...

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Hlavní autoři: Zhang, Litu, Tümer, Zeynep, Møllgård, Kjeld, Barbi, Gotthold, Rossier, Eva, Bendsen, Eske, Møller, Rikke Steensbjerre, Ullmann, Reinhard, He, Jian, Papadopoulos, Nickolas, Tommerup, Niels, Larsen, Lars Allan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2986559/
https://ncbi.nlm.nih.gov/pubmed/19172993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2008.269
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